职    称

研究员

出生年月

1968.10

导师类别

硕导

导师学位

博士

联系电话

15822005360

E-mail

Fengyn2016@163.com

招生要求

无

研究方向

中药及复方药理和毒理研究，中药免疫药理学，现代中药研发

简    介

冯宇新生于中国天津市，1990毕业于青岛海洋大学（中国海洋大学）生物学专业，1997年获得南开大学分子生物学硕士学位，2007年获得美国辛辛那提大学（University   of Cincinnati）细胞和癌症生物学博士学位，部分研究成果发表于美国国家科学院院报（PNAS）。2009-12年担任美国辛辛那提儿童医院医学中心(Cincinnati   Children’s Hospital Medical Center)博士后，2013-14任美国辛辛那提儿童医院医学中心研究员，   2014-16年任美国密西根波普医疗系统成人造血干细胞实验室研究员。 2016年-今任天津中医药大学中医药研究院研究员，天津市外籍高层次专家。2019.12月-今任组分中药国家重点实验室研究员。此外，任Bioorganic   Chemistry, Frontiers in Pharmacology 和Inflammation 等期刊审稿人，世界中医药学会联合会气血专业委员会委员，中华中医药协会治未病分会委员,天津市抗衰老协会血液病专业委员会委员。主要研究方向为中西医结合治疗复杂性疾病，复方中药免疫调节和现代中药研发。在国际一流期刊发表学术论文30余篇，其中《PNAS》二篇,《Genes   & Development》一篇,《Journal   of Clinical Investigation》一篇，《Stem Cell Reports》一篇,   第一作者论文SCI   影响因子最高为9.5。2017年获得国家自然科学基金面上项目1项，2018年获天津市教委科研资助一项。近年申请中国专利二项。2019年获得国家自然科学基金面上项目1项。教授中西医结合临床医学本科生“组织胚胎学”（英文授课）和“微生物和免疫学”（英文授课）。教授研究生“生物医学基础”，“实验药理学”，“专业英语”和“微生物学进展”等课程。

科研项目：

1.   国家自然科学基金面上项目（81973581），一类干扰素信号通路在血必净预防真菌性脓毒症进程中的作用研究,    2020.1-2023.12，在研，主持，55万元。

2.   国家自然科学基金面上项目（81774018），血必净在异基因造血干细胞移植后防治急性GVHD的免疫调节作用及其对受者肠道菌群的影响,   2018.1-2019.12，已结题，主持

3.   国家自然科学基金重点项目（H29   81830112），基于肠道菌群中西医结合防治糖脂代谢疾病的机制研究，2019.1-2023.12，参与

4.   天津市教育委员会 天津市高等学校创新团队   (TD13-5046), 细胞表型导向的中药安全性预测和评估, 2018.1-2021.12，在研，主持

5.   南开大学微生物重点实验室开放课题，血必净预防白念珠菌感染的机制研究，   2017.10-2019.10, 已结题，主持

5. CancerFreeKids (Cincinnati, OH, USA), 针对骨髓微环境治疗急性白血病   (Targeting bone marrow niche to eradicate childhood acute myeloid leukemia   (AML))，   2013.6-2014.6, 已结题, 主持

6. 中国江苏省科委, CD133阳性内皮前体细胞的工业化制备,       2011.7-2013.7, 已结题, 主持

7.  NIH training grant at University of   Cincinnati: The role of Cdc42 in bone

marrow endothelial cells and hematopoiesis (PI)   2009.12-2012.12; 已结题, 主持

8. 基因泰克制药公司和博尔诚公司科研项目(Genentech   Pharmaceutical &

BioChain Institute Inc. CA, USA): 建立小鼠骨髓内皮细胞原代培养的新方法   (Novel Method to establish murine bone marrow endothelial primary culture),   2008.10-2009.10, 已结题, 主持

部分论文：

Xin-Tong Wang, Zhen Peng, Ying-Ying An, Ting Shang,   Guang-Xu Xiao, Shuang He, Xi Chen, Han Zhang, Yue-Fei Wang, Tao Wang, Jun-Hua   Zhang, Xiumei Gao, Yan Zhu, and Yuxin Feng. Paeoniflorin and Hydroxysafflor   Yellow A in Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction   and Inhibit Proinflammatory Cytokine Production. Front Pharmacol. 2021. doi:   10.3389/fphar.2020.614024.

Zhengcan Zhou, Ting Shang, Xiurong Li, Hongyan Zhu,   Yu -Bo Qi, Xin Zhao, Xi Chen, Zhe-Xin Shi, Guixiang Pan, Yuefei Wang, Guanwei   Fan, Xiumei Gao, Yan Zhu and Yuxin Feng. Frontiers in Physiology. 2021.   Protecting intestinal microenvironment alleviates acute Graft vs. Host   Disease", DOI: 10.3389/fphys.2020.608279.

Shang T, Yu Q, Ren T, Wang XT, Zhu H, Gao JM, Pan G,   Gao X, Zhu Y, Feng Y, Li MC. Xuebijing Injection Maintains GRP78 Expression   to Prevent Candida albicans-Induced Epithelial Death in the Kidney. Front   Pharmacol. 2020 Jan 6;10:1416. doi: 10.3389/fphar.2019.01416. eCollection   2019. PubMed PMID:31969817; PubMed Central PMCID: PMC6956827. IF=3.8

朱红艳,冯宇新.浅谈中西医结合系统防治急性移植物抗宿主病[J].天津中医药大学学报,   2020,39(4):470-475.

Liu X, Shao R, Yang X, Xiao G, He S, Feng Y, Zhu Y.   Untargeted Safety Pharmacology Screen of Blood-Activating and Stasis-Removing   Patent Chinese Herbal Medicines Identified Nonherbal Ingredients as a Cause   of Organ Damage in Experimental Models. Front Pharmacol. 2019 Sep 12; 10:993.   doi:10.3389/fphar.2019.00993. eCollection 2019. PubMed PMID: 31607901; PubMed   Central.PMCID: PMC6757273.

Chen X, Chen X, Gao J, Yang H, Duan Y, Feng Y, He X,   Gong X, Wang H, Wu X, Chang J. Astragaloside III Enhances Anti-Tumor Response   of NK Cells by Elevating NKG2D and IFN-γ. Front Pharmacol. 2019 Aug 13;   10:898. doi:10.3389/fphar.2019.00898. eCollection 2019. PubMed PMID: 31456687;   PubMed Central PMCID: PMC6701288. IF=3.8

Hochstetler CL, Feng Y, Sacma M, Davis AK, Rao M,   Kuan CY, You LR, Geiger H, Zheng Y. (2019) KRasG12D expression in the bone   marrow vascular niche affects hematopoiesis with inflammatory signals.    Exp Hematol. 2019 Oct 24. pii: S0301-472X(19)31074-4. doi:   10.1016/j.exphem.2019.10.003. [Epub ahead of print] PMID:31669153

Lyu M, Zhou Z, Wang X, Lv H, Wang M, Pan G, Wang Y,   Fan G, Gao X, Feng Y and Zhu Y (2018) Network Pharmacology-Guided Development   of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease.   Front. Pharmacol. 9:1440. doi: 10.3389/fphar.2018.01440. IF=3.8

Liu H, He S, Wang T, Orang-Ojong B, Lu Q, Zhang Z,   Pan L, Chai X, Wu H, Fan G, Zhang P, Feng Y, Song YS, Gao X, Karas RH, Zhu Y.   Selected phytoestrogens distinguish roles of ERα transactivation and ligand   binding for anti-inflammatory activity. Endocrinology. 2018 Jul 11. doi:   10.1210/en.2018-00275. [Epub ahead of print] PubMed PMID: 30010822.

Chadwick ML, Lane A, Thomas D, Smith AR, White AR,   Davidson D, Feng Y, Boscolo E, Zheng Y, Adams DM, Gupta A, Veillette A, Chow   LML. Combined mTOR and MEK inhibition is an effective therapy in a novel   mouse model for angiosarcoma. Oncotarget. 2018 May 15; 9(37):24750-24765.   doi: 10.18632/oncotarget.25345. eCollection 2018 May 15. PubMed PMID:   29872503; PubMed Central PMCID: PMC5973867.

Chen X, Feng Y, Shen X, Pan G, Fan G, Gao X, Han J,   Zhu Y. Anti-sepsis protection of Xuebijing injection is mediated by   differential regulation of pro- and anti-inflammatory Th17 and T regulatory   cells in a murine model of polymicrobial sepsis. J Ethnopharmacol. 2018 Jan   30; 211:358-365. doi:10.1016/j.jep.2017.10.001. Epub 2017 Oct 4. PubMed PMID:   28987599.  IF=3.1

Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K,   Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y. RHOA   GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell   Maintenance. Stem Cell Reports. 2017 Dec 12; 9(6):1961-1975. doi:   10.1016/j.stemcr.2017.10.004. Epub 2017 Nov 9. PubMed PMID: 29129684; PubMed   Central PMCID: PMC5785633.

Xiao M, Yang J, Feng Y, Zhu Y, Chai X, Wang Y.   Metaproteomic strategies and applications for gut microbial research. Appl   Microbiol Biotechnol. 2017 Mar 14. doi: 10.1007/s00253-017-8215-7. [Epub   ahead of print] Review. PubMed PMID: 28293710.

Al-Homsi AS, Goodyke A, McLane M, Abdel-Mageed S,   Cole K, Muilenburg M, Feng Y. Post-Transplantation Cyclophosphamide and   Ixazomib Combination Rescues Mice Subjected to Experimental Graft-versus-Host   Disease and Is Superior to Either Agent Alone. Biol Blood Marrow Transplant.   2017 Feb; 23(2):255-261. doi:10.1016/j.bbmt.2016.11.015. PubMed PMID:   27888016.

Al-Homsi AS, Goodyke A, Cole K, Muilenburg M, McLane   M, Abdel-Mageed S, Feng Y. Ixazomib Suppresses Human Dendritic Cell and   Modulates Murine Graft-Versus-Host Disease in a Schedule-Dependent Fashion.   Exp Hematol. 2016 Dec 19. pii: S0301-472X(16)30770-6. doi:   10.1016/j.exphem.2016.12.002. [Epub ahead of print] PubMed PMID: 28007655.

Al-Homsi AS, Feng Y, Duffner U, Al Malki MM, Goodyke   A, Cole K, Muilenburg M, Abdel-Mageed A. Bortezomib for the prevention and   treatment of graft-versus-host disease after allogeneic hematopoietic stem   cell transplantation. Exp Hematol. 2016 Sep; 44(9):771-7. doi:   10.1016/j.exphem.2016.05.005. Review. PubMed PMID: 27224851.

Al-Homsi AS, Roy TS, Cole K, Feng Y, Duffner U.   Post-transplant high-dose cyclophosphamide for the prevention of   graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Apr;   21(4):604-11. doi: 10.1016/j.bbmt.2014.08.014. Epub 2014 Aug 23. Review.   PubMed PMID: 25240817

Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F,   Wang C, Yang Y, Hinton A Jr, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y,   Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate   serotonin neurons to inhibit binge-like eating in mice. J Clin Invest. 2014   Aug 26. pii: 74726. doi:10.1172/JCI74726. [Epub ahead of print] PubMed PMID:   25157819.

Feng Y and Zheng Y. Oncogenic Insult In Bone Marrow   Endothelial Cells Causes Hematopoietic Abnormalities. November 15, 2013;   Blood: 122 (21): 2461

Feng Y, Singleton DW, Guo C, Gardner A, Pakala S,   Kumar R, Jensen EV, Zhang J and Khan SA. DNA homologous recombination factor   SFR1 physically and functionally interacts with estrogen receptor.PlosOne   July 2013.   http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068075

Sipes NS, Feng Y, Guo F, Lee HO, Chou FS, Cheng J,   Mulloy J, Zheng Y. Cdc42 regulates extracellular matrix remodeling in three   dimensions. J Biol Chem. 2011 Oct 21; 286 (42):36469-77.

Feng Y, Zhou X and Zheng Y. The Rho GTPase Cdc42 Is   a Key Regulator of the Genesis and Function of Bone Marrow Derived   Endothelial-Like Cells. Blood. Nov 2010; 116 (21): 2109.

Liu W, Feng Y, Shang X, Zheng Y. Rho GTPases in   hematopoietic stem/progenitor cell migration. Methods Mol Biol. 2011;   750:307-19.

Feng Y, Manka D, Wagner KU, Khan SA. Estrogen   receptor-alpha expression in the mammary epithelium is required for ductal   and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A. 2007 Sep 11;   104(37):14718-23.

Singleton DW, Feng Y, Yang J, Puga A, Lee AV, Khan   SA. Gene expression profiling reveals novel regulation by bisphenol-A in   estrogen receptor-alpha-positive human cells.

Environ Res. 2006 Jan; 100(1):86-92.

Singleton DW, Feng Y, Chen Y, Busch SJ, Lee AV, Puga   A, Khan SA. Bisphenol-A and estradiol exert novel gene regulation in human   MCF-7 derived breast cancer cells.

Mol Cell Endocrinol. 2004 Jun 30; 221(1-2):47-55.

Ran R, Lu A, Zhang L, Tang Y, Zhu H, Xu H, Feng Y,   Han C, Zhou G, Rigby AC, Sharp FR. Hsp70 promotes TNF-mediated apoptosis by   binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev.   2004 Jun 15; 18(12):1466-81.

Singleton DW, Feng Y, Burd CJ, Khan SA. Nongenomic   activity and subsequent c-fos induction by estrogen receptor ligands are not   sufficient to promote deoxyribonucleic acid synthesis in human endometrial   adenocarcinoma cells. Endocrinology. 2003 Jan; 144(1):121-8.

Valerius MT, Patterson LT, Feng Y, Potter SS. Hoxa   11 is upstream of Integrin alpha8 expression in the developing kidney. Proc   Natl Acad Sci U S A. 2002 Jun 11; 99(12):8090-5.

会议论文

Lyu M, Zhou Z, Zhu H, Shang T, Pan G, Fan G, Feng Y,   Gao X, Li M and Zhu Y. TO KILL TWO BIRDS WITH ONE STONE: A POTENTIAL STRATEGY   TO PREVENT FUNGAL INFECTION AND GRAFT-VERSUS- HOST DISEASE IN ALLOGENIC   HEMATOPOIETIC TRANSPLANTATION RECIPIENTS. Shock. June 2018 Vol.49 Supp. 1,   p98. 41th Annual Conference on Shock, Scottsdale, Arizona, June 9-12, 2018.

Feng Y*, Goodyke A, Muilenberg M, Cole, K, Cannady   K, Shen A, and Al-Homsi AS, Ixazomib Impairs Dendritic Cell Function and T   Cell Proliferation and Affects the Development of GvHD in a   Schedule-Dependent Fashion. American Society of Hematology Meeting, Orlando,   FL, USA, Dec. 5, 2015.

Feng Y, Zou X, Liu W, Guo F, Liu M, Sampson L, You   L-R, Kuan C-Y and Zheng Y. Rho Gtpase Cdc42 Is Essential for Endothelial   Niche Maintenance in the Bone Marrow and Hematopoiesis. Blood (ASH Annual   Meeting Abstracts), Nov 2012; 120 (21): 508.

Feng Y, Liu M, Guo F, Liu W, Sampson L, You L-R,   Kuan C-Y and Zheng Y. Novel Method to Study Mouse Bone Marrow Endothelial   Cells in Vivo and in Vitro. Blood. Nov 2012; 120 (21): 617.