职    称

助理研究员

出生年月

1993.11

导师类别

硕 导

导师学位

博士

联系电话

E-mail

dkztcm@tjutcm.edu.cn

招生要求

无

研究方向

中药绿色质量评价及药效物质表征新方法研究

简    介

 杜昆泽，医学博士，硕士生导师。依托于现代中药创制全国重点实验室、组分中药国家重点实验室等科研平台，聚焦中药质量评价及药效物质表征新方法研究。主持国家自然科学基金等项目4项，参与国家重点研发计划项目、国家自然科学基金面上项目、横向课题等10余项。参编英文、中文专著2部;共发表SCI论文50余篇，其中以通讯/第一作者(含共一)在ACS Sensors, Sensors & Actuators: B.Chemical, Food Chemistry, Talanta, Journal of Ethnopharmacology, Journal of Chromatography A等期刊发表SCI论文29篇，总引用700余次。申请发明专利9项，相关学术成果以主要完成人获2024年天津市科技进步奖二等奖、2023年中华中医药学会科学技术奖三等奖。担任中华中医药学会中药分析分会青年委员、中药炮制分会青年委员，Traditional Medicine Research杂志青年编委，Food Chemistry、Food Research International、Journal of Ethnopharmacology等杂志审稿人。

代表性论文：

[1] Kunze Du, Bing Wang, Shujing Chen, Yan Cui, Shuangqi Wang, Chunxiao Liang, Ye Shang, Chenhong Wang, Shixin Hou, Jin Li, Xie-an Yu, Yanxu Chang*. A novel strategy for sensitive detection of thrombin via subtly integrated polypeptide substrate and aggregation-induced emission fluorophores in carotid artery thrombosis. Sensors & Actuators: B. Chemical, 2022, 370:132447.

[2] Kunze Du, Yan Cui, Shujing Chen, Rui Yang, Ye Shang, Chenhong Wang, Yiqi Yan, Jin Li, Yanxu Chang. An integration strategy combined progressive multivariate statistics with anticoagulant activity evaluation for screening anticoagulant quality markers in Chinese patent medicine. Journal of Ethnopharmacology, 2022, 287: 114964.

[3] Shujing Chen^#, Kunze Du^#, Shuangqi Wang, Chunxiao Liang, Ye Shang, Xiaoyuan Xie, Ge Tang, Jin Li, Bing Wang, Xie-an Yu, and Yanxu Chang*. A Non-Immunized and BSA-Template Aggregation-Induced Emission Sensor for Noninvasive Detection of Cystatin C in the Clinical Diagnosis of Diabetes Nephropathy. ACS Sensors. 2023. （^#The authors contributed equally）

[4] Kunze Du, Yan Cui, Shujing Chen, Rui Yang, Ye Shang, Chenhong Wang, Yiqi Yan, Jin Li, Yanxu Chang*. An integration strategy combined progressive multivariate statistics with anticoagulant activity evaluation for screening anticoagulant quality markers in Chinese patent medicine. Journal of Ethnopharmacology, 2022, 287: 114964.

[5] Yan Cui^#, Kunze Du^#, Shixin Hou, Rui Yang, Lina Qi, Jin Li, Yanxu Chang*. A comprehensive strategy integrating metabolomics with multiple chemometric for discovery of function related active markers for assessment of foodstuffs: A case of hawthorn （Crataegus cuneata） fruits. Food Chemistry, 2022, 383: 132464. （#The authors contributed equally）

[6] Kunze Du, Jin Li, Yun Bai, Mingrui An, Xiu-mei Gao, Yanxu Chang*. A green ionic liquid-based vortex-forced MSPD method for the simultaneous determination of 5-HMF and iridoid glycosides from Fructus Corni by ultra-high performance liquid chromatography. Food Chemistry, 2018, 244:190-196.

[7] Kunze Du, Tianyu Liu, Wentao Ma, Jiading Guo, Shujing Chen, Jiake Wen, Rui Zhou, Yan Cui, Shuangqi Wang, Li Li, Jin Li, Yanxu Chang. A global profiling strategy for identification of the total constituents in Chinese herbal medicine based on online comprehensive two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry combined with intelligentized chemical classification guidance. Journal of Chromatography A. 2023, 1710:464387.

[8]Xicheng He, Wenliang Ji, Sijia Xing, Zhixuan Feng, Hongyan Li, Shanshan Lu, Kunze Du*, Xiaoxia Li*. Emerging trends in sensors based on molecular imprinting technology: Harnessing smartphones for portable detection and recognition. Talanta. 2023, 268:125283.

[9] Qianqian Zhang, Shujing Chen, Jiake Wen, Rui Wang, Jin Lu, Abdulmumin Muhammad-Biu, Shaoxia Wang, Kunze Du*, Wei Wei, Xiaoxuan Tian, Jin Li, Yanxu Chang*. A comprehensive strategy integrating metabolomics with DNA barcoding for discovery of combinatorial discriminatory quality markers: A case of Cimicifuga foetida and Cimicifuga dahurica, Arabian Journal of Chemistry, 2024, 17, 105613

[10] He Xicheng, Yuming Wang, Li Haixiang, Min Han, Zhixuan Feng, Kunze Du*, Xiaoxia Li*, Approach for concurrent detection and removal of diclofenac in wastewater: Integration of MOF with Poly(deep eutectic solvent) imprinting method，Journal of Environmental Chemical Engineering, 2024.

[11] Xue Meng, Yang Liu, Liu Suyi, Qianqian Zhang, Kunze Du*, Ogaji Omachi Daniel , Lirong Wang , Xingyue Jin , Jin Li , Yanxu Chang*. A review of Viticis Fructus: botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications，Arabian Journal of Chemistry, 2024.

[12]Jiake Wen , Huihui Sun, Guoming Zhang , Haixiang Li , Haishuo Ren, Xiaoxia Li, Jin Li, Kunze Du*, Yanxu Chang*. Green microextraction using deep eutectic solvents: Computer-aided analysis of bioactive components in natural products. Industrial Crops & Products,2025, 224, 120366

[13]Huihui Sun, Jiake Wen, Shujing Chen, Yuli Han, Omachi Daniel Ogaji, Abdulmumin Muhammad Biu, Huan Cui, Xue Meng, Jin Li, Kunze Du*, Yanxu Chang*. Review of advancement in aggregation-induced emission-based fluorescent biosensors for enzyme detection: Mechanisms and biomedical applications. Analytica Chimica Acta, 2025, 1346, 343716.